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Unlike a traditional socket prosthesis, an osseointegrated (OI) prosthesis attaches directly to the bone of the residual limb. OI prostheses provide upper-extremity amputees increased range of motion, more natural movement patterns, and enhanced proprioception. However, the direct skeletal attachment of the prosthesis elevates the risk of bone fracture. To minimize the risk of fracture, it's important to mechanically characterize the bone-prosthesis interface under the same conditions that it would experience in vivo. In this project, I robotically replicate the motion of the humerus as recorded via motion capture while subjects performed activities typical of an active amputee. The robotically replicated motions will be utilized in future investigations to mechanically characterize the bone-prosthesis interface of an OI prosthesis.